NYPI JOURNAL CLUB
STEREOTACTIC HYPOFRACTIONATED ACCURATE RADIOTHERAPY OF
- Berit L. Madsen, M.D.,* R. Alex Hsi, M.D.,* Huong T. Pham, M.D.,* Jack F. Fowler, D.Sc., Ph.D., Laura Esagui, C.M.D.,* And John Corman, M.D.! *Sections of Radiation Oncology and !Urology, Virginia Mason Medical Center, Seattle, WA; Emeritus, Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI
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A comparison of overall survival between patients with low- and intermediate-risk prostate cancer treated with brachytherapy, external beam radiotherapy, or radical prostatectomy.
- J. P. Ciezki, C. A. Reddy, P. A. Kupelian, E. A. Klein, C. Robinson, N. Chehade, K. Angermeier, A. Altman, J. Ulchaker
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Prostate Cancer in Fathers With Fewer Male Offspring: the Jerusalem Perinatal Study Cohort
- Susan Harlap, Ora Paltiel, Yehiel Friedlander, Ronit Calderon-Margalit, Lisa Deutsch, Karinne R. Kleinhaus, Orly Manor, Alfred I. Neugut, Mark Opler, Mary C. Perrin, Mary B. Terry, Efrat Tiram, Rivka Yanetz
Affliliations of authors: Department of Epidemiology, Mailman School of Public Health (SH, AIN, MO, MCP, MBT), and Department of Psychiatry (KRK), Columbia University, New York, NY; Epidemiology Unit, Braun School of Public Health, Hebrew University-Hadassah School of Public Health, Jerusalem, Israel (OP, YF, RCM, LD, OM, ET, RY)
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Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial.
- Greenspan SL, Nelson JB, Trump DL, Resnick NM.University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
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Prostate Specific Antigen Density Correlates
- Shilajit D. Kundu, Kim Yu, Jo Ann V. Antenor, Brian K. Suarez and William J. Catalona, Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (SDK, XY, WJC), and the Departments of Psychiatry (KAR, BKS) and Neurology (JVA), Washington University, School of Medicine, St. Louis, Missouri
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April 17, 2007 - Recent studies have suggested the involvement of loci on the Y chromosome in prostate cancer. We studied the relative risk (RR) of prostate cancer in relation to sex ratio of offspring in a cohort of 38 934 Israeli men who were followed from the birth of their offspring (in 1964 through 1976) until 2005. Cox models were used to adjust for changes in incidence over time, age, the man's year of birth, and social and ethnic variables. A total of 712 men were diagnosed with prostate cancer. Compared with men who had at least one son, men with only daughters had an increased risk of prostate cancer (adjusted RR = 1.40, 95% confidence interval [CI] = 1.20 to 1.64, P<.0001). In men with one, two, or three or more offspring, the relative risks associated with absence of sons were 1.25 (95% CI = 1.00 to 1.56), 1.41 (95% CI = 1.04 to 1.91), and 1.60 (95% CI = 1.05 to 2.43), respectively. Men with no daughters showed no statistically significantly altered risk, compared with men who had offspring of both sexes. The relative risk of prostate cancer decreased as the number of sons increased (Ptrend<.0001) but did not change with the number of daughters. These findings suggest that a Y chromosome locus may be involved in prostate cancer risk in this population.
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